Gastrin Releasing Peptide Lys(Biotin), human is a biotinylated synthetic peptide derived from human gastrin-releasing peptide (GRP), featuring a biotin moiety covalently linked to a lysine residue within the 27-amino acid sequence. This modification retains the native GRP’s high-affinity binding to gastrin-releasing peptide receptors (GRPR), which are overexpressed in various cancers (e.g., prostate, breast, small-cell lung cancer), while enabling sensitive detection and affinity-based applications through streptavidin interactions. The biotin tag facilitates downstream uses such as receptor binding assays, fluorescent or radiolabeled imaging of GRPR-positive cells/tumors, and targeted drug delivery systems, where it serves as a ligand to direct therapeutic payloads to cancer cells. Ideal for both basic research into GRPR signaling pathways and translational studies, this peptide combines the biological specificity of human GRP with the technical advantages of biotin conjugation, supporting advancements in molecular imaging and receptor-targeted cancer therapies.

Chemical Formula: C130H204N38O31S2

Molecular Weight: 2859.30

Sequence: Val-Pro-Leu-Pro-Ala-Gly-Gly-Gly-Thr-Val-Leu-Thr-Lys-Met-Tyr-Pro-Arg-Gly-Asn-His-Trp-Ala-Val-Gly-His-Leu-Met-Lys(Biotin)

Purity: From crude to 98%

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Research Use Only