Big Gastrin - 1, human is a 34 - amino acid polypeptide hormone produced by G cells in the stomach antrum and duodenum. As a precursor form of gastrin, it plays a key role in regulating gastric acid secretion, stimulating the proliferation of gastric mucosal cells, and influencing gastrointestinal motility. This hormone binds to cholecystokinin B receptors (CCKBR) on parietal cells and enteroendocrine cells, triggering acid production and modulating digestive processes. Elevated levels of Big Gastrin - 1 are associated with conditions like Zollinger - Ellison syndrome (gastrinomas) and may contribute to gastric hyperacidity and mucosal hyperplasia. Studying its structure and function aids in understanding gastrointestinal homeostasis and developing therapies for disorders involving abnormal gastrin signaling.

Chemical Formula: C176H251N43O53S

Molecular Weight: 3849.30

Sequence: Pyr-Leu-Gly-Pro-Gln-Gly-Pro-Pro-His-Leu-Val-Ala-Asp-Pro-Ser-Lys-Lys-Gln-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2

Purity: From crude to 98%

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