Gastrin Releasing Peptide, human is a 27-amino acid neuropeptide belonging to the bombesin family, primarily produced by neurons in the central nervous system and endocrine cells in the gastrointestinal (GI) tract. It acts as a key regulator of gastric function by stimulating the release of gastrin from gastric G cells, which in turn promotes hydrochloric acid secretion and mucosal cell growth. This peptide binds to gastrin-releasing peptide receptors (GRPR), triggering signaling pathways involved in GI motility, inflammation, and cell proliferation. Dysregulated GRP signaling is associated with conditions like gastric hyperacidity and cancers (e.g., prostate, breast, small-cell lung cancer), where GRPR is often overexpressed. In research, human gastrin-releasing peptide serves as a critical tool to study GRPR-mediated pathways, develop targeted imaging agents for cancer detection, and explore receptor-specific therapies aimed at inhibiting tumor growth or modulating GI function.

Chemical Formula: C130H204N38O31S2

Molecular Weight: 2859.40

Sequence: Val-Pro-Leu-Pro-Ala-Gly-Gly-Gly-Thr-Val-Leu-Thr-Lys-Met-Tyr-Pro-Arg-Gly-Asn-His-Trp-Ala-Val-Gly-His-Leu-Met-NH2

Purity: From crude to 98%

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