Pentagastrin is a synthetic pentapeptide composed of the C-terminal five amino acids of gastrin (Ala-Trp-Met-Asp-Phe-NH₂), designed to mimic the biological activity of natural gastrin. It acts as a potent stimulator of gastric acid secretion by binding to cholecystokinin type 2 receptors (CCK2R) on gastric parietal cells, making it valuable in clinical settings for diagnosing conditions like Zollinger-Ellison syndrome (excessive acid production) and assessing gastric function in patients with suspected hypochlorhydria or achlorhydria. In research, Pentagastrin is used to study gastrin receptor signaling, gastrointestinal physiology, and the effects of acid-related therapies. Its synthetic nature and receptor specificity make it a critical tool for both diagnostic applications and investigations into gastric acid regulation and digestive system disorders.

Chemical Formula: C37H50N7O9S1

Molecular Weight: 768.79

Sequence: Boc-beta-Ala-Trp-Met-Asp-Phe-NH2

Purity: From crude to 98%

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Research Use Only