Gastrin I (1-14) (human) is a 14-amino acid N-terminal fragment of human gastrin, a hormone essential for regulating gastric acid secretion and gastrointestinal mucosal growth. Derived from the larger gastrin precursor, this peptide retains the core sequence required for binding to cholecystokinin type 2 receptors (CCK2R) on parietal and enteroendocrine cells, initiating signaling pathways that stimulate acid production and cell proliferation. While less potent than full-length gastrin, Gastrin I (1-14) is used in research to study receptor-ligand interactions, assess gastrin-mediated signaling mechanisms, and develop inhibitors targeting abnormal gastrin activity associated with conditions like gastric hyperacidity, ulcers, or gastrin-dependent cancers. Its role as a bioactive fragment provides insights into gastrointestinal physiology and pathobiology, supporting both basic research and therapeutic development.

Chemical Formula: C79H100N16O27

Molecular Weight: 1705.76

Sequence: Pyr-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp

Purity: From crude to 98%

If there are no products available iwth the required purity and quantity, please inform us of your specifications and send an email to sales@alanscientific.com

Our representitives will respond within 24 hours

Research Use Only