Gastrin-1, human is a 17-amino acid peptide hormone primarily produced by gastric G cells in the antrum of the stomach and duodenum, playing a central role in regulating gastric acid secretion and mucosal growth. As a key regulator of the digestive system, it binds to cholecystokinin B (CCK-B) receptors on parietal cells to stimulate hydrochloric acid production and on enterochromaffin-like cells to promote histamine release, enhancing digestive function. Gastrin-1 also influences gastrointestinal mucosal proliferation, contributing to tissue repair and maintenance. Dysregulated gastrin-1 secretion is associated with conditions like Zollinger-Ellison syndrome (due to gastrinomas) and may be linked to gastric cancer, as elevated levels can drive abnormal cell growth. In research, it serves as a critical marker for studying gastrointestinal physiology, acid-related disorders, and neoplastic conditions, while clinical applications include diagnosing hypergastrinemia and monitoring treatment responses in digestive diseases.

Chemical Formula: C97H125N20O31S

Molecular Weight: 2098.22

Sequence: Pyr-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2

Purity: From crude to 98%

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