$2205.00 - $6616.00
Fmoc-Ser-Ser-OH is an Fmoc-protected Ser-Ser dipeptide with two unprotected serine side-chain hydroxyl groups and a free C-terminal carboxyl.
The fragment is useful when a Ser-Ser motif is required and the free hydroxyls are intended for later phosphorylation, glycosylation or other O-functionalization, or when the route can tolerate unprotected hydroxyls during assembly.
Product Information
| Product Name | Fmoc-Ser-Ser-OH |
| Catalog No. | AS4111 |
| CAS No. | 911379-40-3 |
| Molecular Formula | C21H22N2O7 |
| Molecular Weight | 414.41 g/mol |
| Material / Building Block Type | Fmoc-protected Ser-Ser dipeptide with free hydroxyls |
| Primary Applications | Ser-Ser motif installation; phosphorylation precursor chemistry; O-acylation/glycosylation research; convergent peptide synthesis |
Application Scope in Serine-Rich Peptide Design
Ser-Ser motifs occur in phosphorylation-rich regulatory regions and in highly polar peptide sequences. A preassembled fragment can reduce one coupling step while preserving both hydroxyl handles for later modification.
Free Hydroxyl Reactivity
Because the side chains are not tBu-protected, activation and acylation conditions should be selected to limit unwanted O-acylation. Conversely, the free OH groups can be advantageous when selective downstream derivatization is planned.
Procurement and QC
Confirm CAS 911379-40-3, C21H22N2O7, MW 414.41 g/mol, Ser-Ser sequence and L stereochemistry. HPLC/MS should be reviewed for dehydration, acylation or chain-length impurities where relevant.
For phosphorylated, glycosylated or otherwise modified Ser-rich peptides, Alan Scientific can support custom peptide synthesis.
Product Documents
A Safety Data Sheet (SDS / MSDS) is available for this product to support laboratory handling, storage and safety assessment.
Certificates of Analysis (COAs) are batch-specific. Please contact us to request the COA for your product, and we will provide it by email.
Frequently Asked Questions
Are the serine hydroxyl groups protected?
No, not in this product identity.
Can the fragment be used for phosphorylation-oriented designs?
Yes as a precursor motif, with the actual phosphorylation strategy planned for the complete peptide.
Is the C-terminal carboxyl free?
Yes.