$2769.00 - $8308.00
Fmoc-Ala-Gly-OH is an N-Fmoc-protected L-Ala-Gly dipeptide with a free C-terminal glycine carboxyl group. It fixes both sequence direction and L-Ala stereochemistry before the fragment is incorporated into a larger target.
Compared with Fmoc-Gly-Gly-OH, replacing the N-terminal Gly with Ala adds one methyl side chain and removes some local conformational freedom while retaining the same Fmoc-compatible fragment concept.
Product Information
| Product Name | Fmoc-Ala-Gly-OH |
| Catalog No. | AS4183 |
| CAS No. | 116747-54-7 |
| Molecular Formula | C20H20N2O5 |
| Molecular Weight | 368.39 g/mol |
| Building Block Type | Fmoc-protected L-Ala-Gly dipeptide fragment |
| Primary Applications | Fmoc-compatible fragment coupling; Ala-Gly motif installation; convergent peptide synthesis; protected intermediate chemistry |
Ala-Gly Versus Gly-Gly
Ala contributes a small methyl side chain, while Gly has no side-chain carbon. The substitution changes local backbone flexibility and hydrophobicity without introducing a bulky functional group.
Why Use a Preassembled Dipeptide
A verified Ala-Gly fragment removes one downstream coupling step and ensures the Ala-Gly sequence direction is fixed. This can be useful in convergent synthesis or repeated motif construction.
Fmoc Protection Supports Standard N-Terminal Control
The fragment's N-terminus is Fmoc-protected and can be deprotected under standard base-mediated conditions after the fragment is coupled through its free C-terminal carboxyl.
Procurement and QC
Confirm CAS 116747-54-7, C20H20N2O5, MW 368.39 g/mol, sequence Ala-Gly, L-Ala stereochemistry, N-Fmoc protection, and free terminal carboxyl.
Fragment versus stepwise assembly can be chosen based on sequence complexity and scale through custom peptide synthesis.
Product Documents
A Safety Data Sheet (SDS / MSDS) is available for this product to support laboratory handling, storage and safety assessment.
Certificates of Analysis (COAs) are batch-specific. Please contact us to request the COA for your product, and we will provide it by email.
Frequently Asked Questions
Is Fmoc-Ala-Gly-OH the same as Fmoc-Gly-Ala-OH?
No. Sequence direction is different.
Which carboxyl group is free?
The C-terminal Gly carboxyl group is free for further coupling.
Why might a dipeptide fragment be useful?
It can reduce one downstream coupling step and provide a separately characterized sequence unit.
Related Technical Resources
Review peptide assembly in the SPPS guide