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Fmoc-Dap-OH (CAS 181954-34-7) is a Protected amino-acid / peptidomimetic building block selected for a diamino-acid framework whose protecting-group pattern controls orthogonal side-chain functionalization. This positions it within peptide, peptidomimetic and medicinal-chemistry synthesis.
Use when the target structure specifically requires this residue or protection pattern; confirm stereochemistry and deprotection compatibility before substituting it into an established route. Its value is route-specific, so selection should follow the intended transformation rather than the broad category label.
Product Information
| Product Name | Fmoc-Dap-OH |
| Catalog No. | AS4235 |
| CAS No. | 181954-34-7 |
| Molecular Formula | C18H18N2O4 |
| Molecular Weight | 326.35 g/mol |
| Compound Type | Protected amino-acid / peptidomimetic building block |
| Primary Research Use | Peptide, peptidomimetic and medicinal-chemistry synthesis |
Functional Role of the Residue
Fmoc-Dap-OH provides a diamino-acid framework whose protecting-group pattern controls orthogonal side-chain functionalization. In a peptide or small-molecule route, this feature should be introduced deliberately because it can change both synthetic behavior and final molecular properties.
Route Compatibility
Evaluate coupling conditions and deprotection orthogonality with the neighboring residues and other protecting groups already present. The most reliable route is the one designed around the full protection pattern, not an isolated building block.
Browse the unusual residue building blocks for related structures. Complex sequence work can also use specialty peptide building blocks.
Product Documents
The Safety Data Sheet provides product identification, hazard information, handling and storage guidance, exposure controls, transport information, and regulatory information for laboratory use.
Certificates of Analysis (COAs) are batch-specific. Please contact us to request the COA for your product, and we will provide it by email.
Frequently Asked Questions
What is Fmoc-Dap-OH mainly used for?
Peptide, peptidomimetic and medicinal-chemistry synthesis.
What is the critical identity check?
Confirm CAS 181954-34-7, stereochemistry or positional isomer where applicable, and the complete protection state.
What documentation should be matched to the lot?
Use the COA to confirm assay and analytical identity; the nominal formula is C18H18N2O4 with molecular weight 326.35 g/mol.