$571.43 - $1714.29
Fmoc-L-hGln(Trt)-OH is a protected L-homoglutamine derivative in which the side-chain amide is Trt-protected. The side chain contains one additional methylene relative to glutamine, extending the terminal carboxamide farther from the peptide backbone.
This makes the residue useful for amide-spacing SAR when researchers want to retain a Gln-like terminal amide but change its reach and conformational freedom.
Product Information
| Product Name | Fmoc-L-hGln(Trt)-OH |
| Catalog No. | AS2148 |
| CAS No. | 1263046-43-0 |
| Molecular Formula | C40H36N2O5 |
| Molecular Weight | 624.72 g/mol |
| Material / Building Block Type | Fmoc-protected L-homoglutamine side-chain Trt derivative |
| Primary Applications | Backbone-homologated Gln peptide SAR; noncanonical amide side-chain studies; protected homoglutamine incorporation; Fmoc-SPPS |
Application Scope in Homologated Gln SAR
Homoglutamine can be used to probe hydrogen-bonding distance, side-chain reach and conformational tolerance in peptide binding sites. The additional methylene also changes hydrophobicity and rotamer space relative to Gln.
Trt Side-Chain Protection
Trt masks the terminal side-chain amide nitrogen during peptide synthesis and is acid-labile. This protects the homologated amide through activation and chain elongation.
Procurement and QC
CAS 1263046-43-0 is independently indexed as (S)-Fmoc-2-amino-5-(trityl-carbamoyl)pentanoic acid / Fmoc-L-hGln(Trt)-OH. Confirm C40H36N2O5, MW about 624.74 g/mol and L stereochemistry.
Alan Scientific can prepare hGln-containing analog series through custom noncanonical peptide synthesis.
Product Documents
A Safety Data Sheet (SDS / MSDS) is available for this product to support laboratory handling, storage and safety assessment.
Certificates of Analysis (COAs) are batch-specific. Please contact us to request the COA for your product, and we will provide it by email.
Frequently Asked Questions
What does hGln mean?
Homoglutamine, a glutamine homolog with one additional methylene in the side chain.
What does Trt protect?
The terminal side-chain amide nitrogen.
Why use hGln instead of Gln?
To change side-chain reach and hydrogen-bonding geometry while retaining a terminal amide.
Related Technical Resources
Read about noncanonical amino-acid design