$224.00 - $2020.00
(2S)-3-(4,4-Difluorocyclohexyl)-2-(9h-fluoren-9-ylmethoxycarbonylamino)propanoic acid (CAS 2276607-04-4) is supplied as a Halogenated protected amino-acid building block. In research synthesis, it is most relevant to fluorinated residue incorporation in peptide and medicinal-chemistry synthesis and conformational, electronic and hydrophobicity tuning in peptide/SAR studies.
Select for a defined stereochemical and fluorination pattern; the effect of fluorination is position- and sequence-dependent. Procurement should match the exact CAS, protection state and lot-specific analytical specification to the intended route.
Product Information
| Product Name | (2S)-3-(4,4-Difluorocyclohexyl)-2-(9h-fluoren-9-ylmethoxycarbonylamino)propanoic acid |
| Catalog No. | AS4256 |
| CAS No. | 2276607-04-4 |
| Molecular Formula | C24H25F2NO4 |
| Molecular Weight | 429.46 g/mol |
| Compound Type | Halogenated protected amino-acid building block |
| Primary Research Use | Fluorinated residue incorporation in peptide and medicinal-chemistry synthesis |
4,4-Difluorocyclohexyl Side Chain
AS4256 is an N-Fmoc-protected amino acid with (2S) stereochemistry and an unprotected alpha-carboxyl group. Its side chain contains a cyclohexyl ring with two fluorine atoms at the 4-position. For peptide analogue comparisons, identify this specific substitution pattern explicitly. Any effects on the properties or activity of the resulting peptide require evaluation in that peptide.
Selection Considerations
Verify substitution position and stereochemistry before ordering. Positional isomers with the same elemental composition can have materially different synthetic and biological behavior.
Additional chemistry is available in the specialty amino acid set. For synthesis planning beyond the building block, see specialty SPPS building blocks.
Product Documents
The Safety Data Sheet provides product identification, hazard information, handling and storage guidance, exposure controls, transport information, and regulatory information for laboratory use.
Certificates of Analysis (COAs) are batch-specific. Please contact us to request the COA for your product, and we will provide it by email.
Frequently Asked Questions
What is (2S)-3-(4,4-Difluorocyclohexyl)-2-(9h-fluoren-9-ylmethoxycarbonylamino)propanoic acid mainly used for?
Fluorinated residue incorporation in peptide and medicinal-chemistry synthesis.
What is the critical identity check?
Confirm CAS 2276607-04-4, stereochemistry or positional isomer where applicable, and the complete protection state.
What documentation should be matched to the lot?
Use the COA to confirm assay and analytical identity; the nominal formula is C24H25F2NO4 with molecular weight 429.46 g/mol.