$258.00 - $775.00
1-Boc-4-(Fmoc-amino)-piperidine-4-carboxylic acid is an orthogonally protected piperidine amino-acid analog. The piperidine ring nitrogen is Boc-protected, the exocyclic 4-amino group is Fmoc-protected, and the 4-carboxylic acid remains free.
This protection map is the opposite of the closely related Boc-Pip(Fmoc)-OH (CAS 368866-07-3), which has Boc on the exocyclic 4-amino group and Fmoc on the ring nitrogen. The two compounds even share the same formula and MW, so mass alone cannot distinguish them.
Product Information
| Product Name | 1-Boc-4-(Fmoc-amino)-piperidine-4-carboxylic acid |
| Catalog No. | AS4187 |
| CAS No. | 183673-66-7 |
| Molecular Formula | C26H30N2O6 |
| Molecular Weight | 466.53 g/mol |
| Building Block Type | Orthogonally protected 4-aminopiperidine-4-carboxylic acid |
| Primary Applications | Constrained amino-acid analog synthesis; orthogonal amine chemistry; piperidine-containing peptides and peptidomimetics |
Protecting-Group Topology Is the Core Identity
For this product, Boc and Fmoc are not interchangeable labels. They determine which nitrogen can be exposed under acid versus base and therefore define the order of downstream reactions.
Why This Scaffold Is Useful
The piperidine ring places an amino substituent and carboxyl group at a quaternary ring carbon, creating a rigid, nonproteinogenic geometry that can be used in peptide mimetics or constrained linker designs.
Mass Spectrometry Cannot Resolve the Protection Map
Both this compound and CAS 368866-07-3 have C26H30N2O6 and MW 466.53 g/mol. A correct CAS, structural drawing, and protecting-group assignment are therefore essential procurement controls.
Procurement and QC
Confirm CAS 183673-66-7, ring-N Boc, exocyclic NH Fmoc, free carboxylic acid, formula C26H30N2O6, and MW 466.53 g/mol.
When both amines are used sequentially in a constrained scaffold, deprotection order should be designed with the complete target through custom peptide and peptidomimetic synthesis.
Product Documents
A Safety Data Sheet (SDS / MSDS) is available for this product to support laboratory handling, storage and safety assessment.
1-Boc-4-(Fmoc-amino)-piperidine-4-carboxylic acid MSDS
Certificates of Analysis (COAs) are batch-specific. Please contact us to request the COA for your product, and we will provide it by email.
Frequently Asked Questions
Where is the Boc group?
Boc protects the piperidine ring nitrogen.
Where is the Fmoc group?
Fmoc protects the exocyclic amino group at C4.
Why is this easy to confuse with Boc-Pip(Fmoc)-OH?
The related product can have the opposite Boc/Fmoc protection map while sharing the same formula and molecular weight.
Related Technical Resources
Explore noncanonical building-block design