$1895.00 - $5686.00
Fmoc-Gly-Gly-Phe-Gly-OMe is a protected tetrapeptide with the sequence Gly-Gly-Phe-Gly, an Fmoc-protected N-terminus and a C-terminal methyl ester.
The molecule provides a preassembled, flexible-to-aromatic sequence motif for fragment and linker research while keeping the terminal carboxyl masked during intermediate handling.
Product Information
| Product Name | Fmoc-Gly-Gly-Phe-Gly-OMe |
| Catalog No. | AS4149 |
| Molecular Formula | C31H32N4O7 |
| Molecular Weight | 572.62 g/mol |
| Material / Building Block Type | Fmoc-Gly-Gly-Phe-Gly tetrapeptide C-terminal methyl ester |
| Primary Applications | Protected tetrapeptide fragment synthesis; Phe-Gly linker motif research; convergent peptide assembly; conjugation-intermediate chemistry |
Application Scope in Linker and Fragment Chemistry
Gly-rich segments provide flexibility, while Phe introduces an aromatic recognition and hydrophobic element. Gly-Gly-Phe-Gly motifs can be explored in cleavable-linker and peptide-fragment architectures, but enzyme sensitivity must be demonstrated for the complete construct.
Methyl Ester as a Temporary C-Terminal Block
The OMe group prevents direct carboxyl coupling until hydrolyzed or otherwise converted. It is useful when N-terminal extension or other transformations must occur before the C-terminus is activated.
Analytical Identity and QC
Confirm C31H32N4O7, MW 572.62 g/mol, exact sequence, N-Fmoc and C-terminal OMe using the lot-specific COA and LC-MS/HPLC data.
For linker-containing or fragment-based constructs, route order can be evaluated through custom peptide synthesis.
Product Documents
A Safety Data Sheet (SDS / MSDS) is available for this product to support laboratory handling, storage and safety assessment.
Certificates of Analysis (COAs) are batch-specific. Please contact us to request the COA for your product, and we will provide it by email.
Frequently Asked Questions
Does AS4149 have a confirmed CAS number?
No reliable CAS number has been confirmed for AS4149.
Is the C-terminal carboxyl free?
No. It is a methyl ester.
Does the Phe-Gly motif guarantee protease cleavage?
No. Cleavage depends on the complete substrate context and enzyme system.
Related Technical Resources
Review peptide assembly and fragment strategy