$431.00 - $2154.00
Fmoc-D-Val-OH is an Fmoc-protected D-valine building block used for incorporation of D-Val during solid-phase peptide synthesis. The branched isopropyl side chain is non-reactive under standard Fmoc-SPPS conditions and normally requires no additional side-chain protecting group.
D-Val is useful in stereochemical peptide scans, partially D-configured sequences and studies of protease recognition or local backbone geometry. The beta-branched side chain can make coupling more sterically demanding than smaller residues such as alanine, so difficult sequences may benefit from monitoring coupling completeness rather than assuming identical kinetics across all Fmoc amino acids.
Product Information
| Product Name | Fmoc-D-Val-OH |
| Catalog No. | AS3039 |
| CAS No. | 84624-17-9 |
| Molecular Formula | C20H21NO4 |
| Molecular Weight | 339.39 g/mol |
| Protecting Groups | Fmoc alpha-amino protection; no side-chain protecting group |
| Primary Application | D-valine incorporation in Fmoc-SPPS |
Application Scope and Assay Relevance
Primary use: Hydrophobic beta-branched D-valine building block for peptide stereochemical scanning and conformational optimization.
| Typical in vitro relevance | Typical downstream assays include receptor binding, enzyme or cell-signaling assays, protease stability and structural studies. Historical PTH analog studies illustrate that D-Val substitutions can strongly change receptor affinity and biological activity depending on position. |
| In vivo relevance | D-Val-containing peptide analogs have been tested in animal pharmacology, but reduced activity is also well documented for some positions. D-Val is therefore best described as a SAR tool, not an intrinsically activity-enhancing modification. |
Beta branching can affect coupling efficiency
Valine’s isopropyl side chain increases steric congestion near the reacting center. In difficult sequences, coupling completeness may need closer attention than for less hindered residues.
Purchasing and QC Considerations
Confirm CAS 84624-17-9, HPLC purity and enantiomeric purity. Reference peptide-synthesis grades also report clear DMF solubility and separate chiral-purity specifications.
Frequently Asked Questions
Does D-Val need side-chain protection?
No. Its hydrocarbon side chain is normally left unprotected.
Why can valine coupling be slower?
The beta-branched side chain creates greater steric hindrance near the backbone.
What should be checked for D-Val procurement?
CAS identity, chemical purity, enantiomeric purity and lot-specific COA documentation.
Product Documents
A Material Safety Data Sheet (MSDS) is available for this product to support laboratory handling, storage and safety assessment.
Certificates of Analysis (COAs) are batch-specific. Please contact us to request the COA for your product, and we will provide it by email.
Related Technical Resources
See Fmoc-D-Ile-OH for a closely related building block or synthesis resource.
Browse the complete D-Form Amino Acids category or use Alan Scientific's Chemical Peptide Synthesis service for custom peptides containing D-amino acids.