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Dynorphin A amide, porcine is a 17-residue opioid peptide containing the complete Dynorphin A sequence with a C-terminal Gln-NH₂. The N-terminal Tyr-Gly-Gly-Phe-Leu motif provides the classical opioid message region, while the extended basic C-terminal sequence contributes to the distinctive pharmacology of the dynorphin family.
Product Information
| Property | Specification |
|---|---|
| Sequence | Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-Trp-Asp-Asn-Gln-NH₂ |
| One-Letter Sequence | YGGFLRRIRPKLKWDNQ-NH₂ |
| Peptide Length | 17 amino-acid residues |
| Molecular Formula | C99H156N32O22 |
| Molecular Weight | Approximately 2146.55 Da |
| C-Terminus | Gln-NH₂ |
| Research Context | Opioid receptor and dynorphin SAR research |
Opioid Message and Extended Address Region
The first five residues form an enkephalin-like opioid recognition motif. Dynorphin A then extends through a strongly basic region containing multiple Arg and Lys residues, producing receptor interactions that differ from shorter enkephalins.
This architecture has historically been associated with strong κ-opioid receptor pharmacology, although activity at additional opioid targets can occur depending on concentration and experimental context.
C-Terminal Amidation
The listed product terminates in Gln-NH₂. This should be reported explicitly because terminal amidation changes charge and molecular identity compared with a free-carboxyl Dynorphin A sequence.
Analytical Considerations
The peptide contains Trp14 and several basic residues, which influence chromatographic behavior and solution properties. Exact terminal chemistry should be included when comparing literature preparations.