$90.00 - $90.00
Biotin-Neurokinin B is an N-terminally biotinylated derivative of the complete Neurokinin B sequence. The construct combines DMHDFFVGLM-NH₂ with a biotin affinity handle for streptavidin-based detection, immobilization and ligand-interaction studies.
The peptide is best treated as an analytical receptor probe rather than assuming pharmacological equivalence to native Neurokinin B.
Product Information
| Property | Specification |
|---|---|
| Product Name | Biotin-Neurokinin B |
| Catalog No. | AS2632 |
| CAS No. | 1926163-17-8 |
| Sequence | Biotin-Asp-Met-His-Asp-Phe-Phe-Val-Gly-Leu-Met-NH₂ |
| One-Letter Sequence | Biotin-DMHDFFVGLM-NH₂ |
| Molecular Formula | C65H93N15O16S3 |
| Molecular Weight | Approximately 1436.72 Da |
| Modification | N-terminal biotin |
| Reference Receptor | NK3R |
Affinity Tag Added to the Native NKB Scaffold
The complete NKB sequence is retained downstream of the biotin group, including its C-terminal Met-NH₂. Biotin enables interaction with streptavidin or avidin reagents for capture and detection workflows.
Do Not Assume Native NKB Potency
N-terminal biotinylation increases molecular mass and alters the chemical environment of Asp1. The modified peptide may therefore differ from native NKB in affinity, receptor activation or kinetic behavior.
We recommend including unlabeled Neurokinin B as a functional reference whenever receptor potency is an endpoint.
Analytical Considerations
The construct contains three sulfur atoms: one in biotin and two from the methionine residues of NKB. Both methionines remain susceptible to oxidation.
Our Peptide Quality Control capabilities can support conjugate identity by HPLC and mass spectrometry.
Frequently Asked Questions
Where is biotin attached?
The listed construct contains N-terminal biotin before Asp1.
Does biotinylation guarantee unchanged NK3R potency?
No. The modified construct should be evaluated experimentally against native NKB.