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[Met5,Lys6,7]-α-Neo-Endorphin (1-7), also known as Met-Enkephalin-Lys-Lys, is a seven-residue peptide with the sequence Tyr-Gly-Gly-Phe-Met-Lys-Lys.
The molecule combines the Met-enkephalin pharmacophore with a dibasic Lys-Lys C-terminal extension, creating a compact model for opioid peptide processing and basic-residue structure–activity studies.
Product Information
| Property | Specification |
|---|---|
| Product Name | [Met5,Lys6,7]-α-Neo-Endorphin (1-7) |
| Catalog No. | AS2558 |
| Synonyms | Met-Enkephalin-Lys-Lys; Met-Enkephalin-KK |
| CAS No. | 80237-40-7 |
| Sequence | Tyr-Gly-Gly-Phe-Met-Lys-Lys |
| One-Letter Sequence | YGGFMKK |
| Peptide Length | 7 residues |
| Molecular Formula | C39H59N9O9S |
| Molecular Weight | Approximately 830.0 Da |
| C-Terminus | Lys-OH |
A Dibasic Lys-Lys Extension
The first five residues are identical to Met-enkephalin. Addition of Lys6-Lys7 creates a strongly basic C-terminal region that can influence charge, chromatographic behavior and susceptibility to processing enzymes.
The sequence is chemically distinct from the related YGGFMKR analog, in which Arg occupies position 7.
Peptide-Processing Research
Dibasic Lys-Lys and Lys-Arg motifs are common recognition features in peptide-hormone precursor processing. Although this short peptide should not be treated as a complete prohormone substrate, its defined Lys-Lys terminus makes it useful for comparative cleavage and enzyme-recognition studies.
Comparing Lys-Lys and Lys-Arg Variants
| Peptide | Sequence |
|---|---|
| Met-Enkephalin-Lys-Lys | YGGFMKK |
| Met-Enkephalin-Lys-Arg | YGGFMKR |
This single-residue comparison can help isolate the effect of Lys versus Arg at the terminal position without changing the remainder of the peptide.
Frequently Asked Questions
Is this peptide the same as Met-Enkephalin-Lys-Lys?
Yes. Both names describe the sequence YGGFMKK.
Does it contain a C-terminal amide?
No. The listed sequence terminates in Lys with a free carboxyl group.