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Chicken CGRP is a 37-residue avian calcitonin gene-related peptide containing the conserved Cys2-Cys7 disulfide bond and C-terminal Phe-NH₂ characteristic of active CGRP-family peptides.
Its sequence is closely related to mammalian CGRP while containing several strategically positioned substitutions, making it particularly useful for comparative structure–activity and species-dependent receptor studies.
Product Information
| Property | Specification |
|---|---|
| Product Name | Calcitonin Gene-Related Peptide, Chicken |
| Catalog No. | AS2649 |
| Sequence | Ala-Cys-Asn-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala-Asp-Phe-Leu-Ser-Arg-Ser-Gly-Gly-Val-Gly-Lys-Asn-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Lys-Ala-Phe-NH₂ |
| One-Letter Sequence | ACNTATCVTHRLADFLSRSGGVGKNNFVPTNVGSKAF-NH₂ |
| Peptide Length | 37 amino-acid residues |
| Molecular Formula | C165H260N52O50S2 |
| Molecular Weight | Approximately 3836.4 Da |
| Disulfide Bond | Cys2-Cys7 |
| C-Terminus | Phe-NH₂ |
| Research Focus | Avian CGRP biology and comparative structure–activity studies |
Sequence Differences from Human α-CGRP
Chicken CGRP and human α-CGRP contain the same number of residues and preserve the characteristic N-terminal ring and amidated C-terminus. They differ at only a small number of positions, including residues 3, 14, 15 and 23.
These substitutions create a valuable natural structure–activity comparison. In particular, historical synthetic-peptide studies identified residue 14 as an important contributor to the different biological activity observed between chicken and human CGRP in the experimental systems examined.
A Natural Comparative SAR Probe
Instead of introducing arbitrary mutations into a human peptide, chicken CGRP allows researchers to study a naturally occurring sequence with conserved global architecture and localized substitutions.
Published comparisons found chicken CGRP to produce stronger or longer-lasting responses than human CGRP in selected calcium/phosphate and cell-signaling models. These observations are assay-specific and should not be interpreted as universal potency differences across every CGRP receptor system.
We recommend using matched experimental conditions when species variants are compared, particularly because receptor expression and accessory proteins can substantially influence apparent CGRP pharmacology.
Structural Features Relevant to CGRP Activity
The Cys2-Cys7 disulfide ring and C-terminal amidation are conserved structural features of active CGRP. Earlier structure–activity studies found substantial loss of activity when the N-terminal ring was disrupted or when the C-terminal residue and amide architecture were altered.
This makes chicken CGRP useful for experiments that connect natural sequence variation with the conserved structural requirements of the CGRP scaffold.
Research Applications
Applications include avian neuropeptide research, comparative receptor pharmacology, peptide structure–activity analysis and studies of species-dependent CGRP signaling.
For custom sequence variants, residue-swapped analogs or labeled CGRP constructs, researchers can use our Chemical Peptide Synthesis capabilities.
Frequently Asked Questions
Is chicken CGRP identical to human CGRP?
No. The peptides share a highly conserved 37-residue architecture but contain several sequence substitutions.
Why is chicken CGRP useful for structure–activity research?
It provides a naturally occurring sequence variant that preserves the major CGRP structural features while changing selected side chains.
Does chicken CGRP retain the N-terminal disulfide ring?
Yes. The mature peptide contains a Cys2-Cys7 disulfide bond and an amidated C-terminus.