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α-Neoendorphin (1-8) is an eight-residue N-terminal fragment of α-Neoendorphin with the sequence Tyr-Gly-Gly-Phe-Leu-Arg-Lys-Tyr. It retains the Leu-enkephalin-like Tyr-Gly-Gly-Phe-Leu motif together with the basic Arg6-Lys7 extension and Tyr8.
The fragment is useful for examining how removal of the Pro9-Lys10 C-terminal region changes the pharmacological and processing properties of the full prodynorphin-derived peptide.
Product Information
| Property | Specification |
|---|---|
| Product Name | α-Neoendorphin (1-8) |
| Catalog No. | AS2591 |
| CAS No. | 83339-89-3 |
| Sequence | Tyr-Gly-Gly-Phe-Leu-Arg-Lys-Tyr |
| One-Letter Sequence | YGGFLRKY |
| Peptide Length | 8 residues |
| Molecular Formula | C49H70N12O11 |
| Molecular Weight | Approximately 1003.2 Da |
| C-Terminus | Tyr-OH |
Truncating the Prodynorphin-Derived Scaffold
Full-length α-Neoendorphin contains ten residues. Removing Pro9-Lys10 shortens the C-terminal address region while leaving the core opioid motif and Tyr8 intact.
This makes the 1-8 fragment useful for mapping how C-terminal basic and conformational features contribute to receptor preference.
Relation to κ-Opioid Pharmacology
Full-length α-Neoendorphin is a prodynorphin peptide with strong κ-opioid activity in classical receptor systems. Truncation of prodynorphin peptides can shift potency and receptor preference, so α-Neoendorphin (1-8) should be evaluated as its own molecular entity rather than assumed to reproduce the full decapeptide.
Frequently Asked Questions
How does α-Neoendorphin (1-8) differ from full-length α-Neoendorphin?
It lacks the final Pro9-Lys10 residues.
Does it retain the Leu-enkephalin motif?
Yes. Residues 1-5 are Tyr-Gly-Gly-Phe-Leu.