[Asp5,6,Me-Phe8] Substance P (5-11), also known as NH2-senktide or aminosenktide, is a seven-residue synthetic tachykinin analog developed as a selective NK3 receptor agonist.

The peptide combines Asp residues at positions 5 and 6 with an N-methyl-Phe substitution at position 8, producing pharmacology that differs markedly from native Substance P fragments.

Product Information

Why NH2-Senktide Is an NK3 Tool Rather Than an SP Agonist

The combination of acidic Asp residues and backbone N-methylation changes receptor recognition sufficiently to produce strong preference for the NK3 tachykinin receptor system.

This makes the peptide more useful for NK3-specific experiments than its historical Substance P-derived name may suggest.

NK3 Receptor and CNS Research

NH2-senktide has been used in CNS studies involving ingestive behavior, reward-related pathways and neurokinin receptor function.

A radiolabeled derivative of NH2-senktide was used to characterize high-affinity NK3-associated sites in rat brain, with a reported K_d of approximately 0.9 nM for that labeled probe.

We recommend distinguishing this radioligand value from the potency of the unmodified product itself.

Research Applications

NH2-senktide can support NK3 receptor activation studies, CNS tachykinin research, receptor subtype pharmacology and investigations of N-methylated peptide ligands.

Frequently Asked Questions

Is this peptide also called senktide?

It is commonly called NH2-senktide or aminosenktide. It should be distinguished from other senktide derivatives with different terminal modifications.

Is it selective for NK3?

Yes. It is a classical selective NK3 receptor agonist.

What does Me-Phe8 mean?

The residue at position 8 is N-methylphenylalanine, introducing backbone N-methylation.

Research Use Only.