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Rat/mouse Orexin B is a 28-residue amidated hypothalamic neuropeptide and endogenous agonist of orexin receptors. Its rodent sequence differs from the human peptide at defined positions, making it useful for species-matched receptor and neuroscience studies.
Product Information
| Property | Specification |
|---|---|
| Catalog No. | AS2717 |
| CAS No. | 202801-92-1 |
| Sequence | Arg-Pro-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Ala-Asn-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH₂ |
| One-Letter Sequence | RPGPPGLQGRLQRLLQANGNHAAGILTM-NH₂ |
| Peptide Length | 28 amino-acid residues |
| Molecular Formula | C126H215N45O34S |
| Molecular Weight | Approximately 2936.44 Da |
| C-Terminus | Met-NH₂ |
| Primary Receptors | OX1R and OX2R, with stronger OX2-oriented pharmacology |
Species-Matched Rodent Orexin B
Rodent Orexin B differs from human Orexin B at residues near the N-terminal and central regions. These naturally occurring substitutions allow species effects to be evaluated without introducing synthetic mutations.
For rat or mouse tissues and receptor systems, using the corresponding endogenous sequence reduces ambiguity when quantitative ligand responses are compared.
OX2-Oriented Orexin Pharmacology
Orexin B can activate both orexin receptor subtypes, but pharmacological studies generally show stronger activity at OX2R than OX1R. We recommend avoiding the absolute statement that Orexin B is “OX2-only,” because measurable OX1R activity has been demonstrated.
Research Applications
Applications include rodent orexin-receptor signaling, arousal and sleep-state research, feeding circuits, neural excitability and comparison with OX2-selective agonists.
Custom species variants can be evaluated through Chemical Peptide Synthesis.
Frequently Asked Questions
How many residues are in rat/mouse Orexin B?
The mature peptide contains 28 amino-acid residues, not 33.
Is the C-terminus amidated?
Yes. Mature rodent Orexin B terminates in Met-NH₂.