Angiotensin II, human is an octapeptide (8 amino acids) and a key effector molecule in the renin-angiotensin system (RAS), generated by angiotensin-converting enzyme (ACE)-mediated cleavage of angiotensin I. As a potent vasoactive peptide, it binds to angiotensin type 1 (AT1) and type 2 (AT2) receptors, mediating vasoconstriction, aldosterone secretion, sodium retention, and cell proliferation—critical for regulating blood pressure, fluid balance, and cardiovascular homeostasis. Dysregulation of Angiotensin II signaling is linked to hypertension, heart failure, atherosclerosis, and diabetic nephropathy. In pharmacological research, human Angiotensin II serves as a tool to investigate RAS pathway activation, receptor pharmacology, and the development of therapies like angiotensin receptor blockers (ARBs) and ACE inhibitors. Its role in both physiological regulation and pathological conditions highlights its significance as a target for treating cardiovascular and renal disorders, while its synthetic forms enable precise studies of receptor-mediated responses and drug discovery.

Chemical Formula: C50H71N13O12

Molecular Weight: 1046.19

Sequence: Asp-Arg-Val-Tyr-Ile-His-Pro-Phe

Purity: From crude to 98%

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