Ac-Angiotensinogen (1-14), human is a 14-amino-acid synthetic peptide corresponding to the N-terminal fragment (residues 1–14) of human angiotensinogen, with an N-terminal acetyl (Ac-) modification. As the native substrate for renin in the renin-angiotensin system (RAS), this peptide contains the primary cleavage site recognized by renin, which generates angiotensin I (a precursor to the vasoactive peptide angiotensin II). The acetyl modification enhances stability and membrane permeability, making it a valuable tool in pharmacological research to investigate renin binding specificity, enzyme-substrate interactions, and the initial steps of RAS activation. It supports studies on blood pressure regulation, fluid homeostasis, and the development of renin inhibitors for treating hypertension and heart failure. By mimicking the natural renin substrate, Ac-Angiotensinogen (1-14) aids in characterizing RAS signaling mechanisms and evaluating therapeutic strategies targeting the earliest stage of angiotensin biosynthesis.

Chemical Formula: C85H124N24O20

Molecular Weight: 1802.10

Sequence: Ac-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Asn

Purity: From crude to 98%

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