Angiotensin II Antipeptide is a synthetic peptide designed to specifically bind and neutralize the bioactivity of angiotensin II, a key vasoactive octapeptide in the renin-angiotensin system (RAS). These peptides typically mimic the structure of angiotensin II or its receptor-binding domains but act as competitive inhibitors, blocking interactions with angiotensin type 1 (AT1) and type 2 (AT2) receptors. By preventing angiotensin II-mediated vasoconstriction, aldosterone secretion, and pro-inflammatory signaling, Angiotensin II Antipeptides serve as valuable tools in pharmacological research to investigate RAS signaling pathways, receptor specificity, and the therapeutic potential of receptor antagonism. They are used to study blood pressure regulation, cardiovascular remodeling, and renal function, while also facilitating the development of drugs like angiotensin receptor blockers (ARBs) for treating hypertension, heart failure, and diabetic nephropathy. Their design often focuses on enhancing binding affinity and selectivity, making them essential for mechanistic studies and translational applications targeting RAS-related disorders.

Chemical Formula: C42H62N10O12

Molecular Weight: 899.02

Sequence: Glu-Gly-Val-Tyr-Val-His-Pro-Val

Purity: From crude to 98%

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