Biotin - Angiotensin I, human is a biotinylated derivative of the human angiotensin I decapeptide (10 amino acids), featuring a covalently attached biotin moiety for easy detection and purification in biochemical and pharmacological studies. As the natural substrate for angiotensin-converting enzyme (ACE) in the renin-angiotensin system (RAS), this conjugate retains the ability to be processed by ACE into angiotensin II, while the biotin tag enables visualization or isolation of interactions with ACE, renin, or angiotensin receptors (e.g., via streptavidin-based assays). In research, it serves as a valuable tool to investigate enzyme-substrate interactions, receptor binding kinetics, and RAS signaling pathways, facilitating studies on blood pressure regulation, cardiovascular pharmacology, and the development of ACE inhibitors or angiotensin receptor blockers (ARBs). Its biotinylation enhances utility in affinity chromatography, ELISA, or cell-based assays to characterize binding specificity and modulate RAS activity, making it essential for both basic and translational investigations into RAS-related disorders like hypertension and heart failure.

Chemical Formula: C72H103N19O16S

Molecular Weight: 1522.81

Sequence: Biotin-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu

Purity: From crude to 98%

If there are no products available iwth the required purity and quantity, please inform us of your specifications and send an email to sales@alanscientific.com

Our representitives will respond within 24 hours

Research Use Only