β-Amyloid Peptide (1-42), rat is a 42-amino acid peptide derived from the rat amyloid precursor protein (APP), corresponding to the N-terminal to residue 42 of the β-amyloid (Aβ) sequence. While structurally similar to human Aβ(1-42), it contains species-specific amino acid variations that affect its biophysical properties, such as aggregation kinetics and interaction with cellular receptors or processing enzymes. In rats, Aβ peptides are involved in normal neural processes like synaptic signaling and neuroinflammation, though rats do not naturally develop amyloid plaques associated with Alzheimer’s disease. This peptide is used in research to investigate interspecies differences in Aβ biology, including how sequence variations impact aggregation propensity, toxicity, and clearance mechanisms. By comparing rat and human Aβ(1-42), scientists gain insights into conserved and divergent pathways of Aβ-mediated neurotoxicity, supporting the development of preclinical models for testing anti-amyloid therapies and understanding the evolutionary basis of amyloid-related disorders.

Chemical Formula: C199H307N53O59S

Molecular Weight: 4418.05

Sequence: Asp-Ala-Glu-Phe-Gly-His-Asp-Ser-Gly-Phe-Glu-Val-Arg-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala

Purity: From crude to 98%

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Research Use Only