[Val35]-β-Amyloid (1-42) is a synthetic peptide variant of the amyloid β (Aβ) protein, featuring a valine (Val) substitution at the 35th amino acid position, a site within the hydrophobic core region critical for Aβ aggregation and fibril formation. This modification alters the peptide’s hydrophobic interactions and conformational stability, potentially influencing its propensity to form toxic oligomers and amyloid plaques, which are hallmarks of Alzheimer’s disease. Aβ(1-42) is known for its high aggregator potential and neurotoxicity, and the [Val35] variant is used in research to investigate how amino acid changes in the hydrophobic domain affect aggregation kinetics, fibril morphology, and interaction with cellular components like membranes or chaperone proteins. By studying this variant, scientists aim to better understand the molecular mechanisms underlying Aβ misfolding, evaluate the impact of structural modifications on pathological signaling, and develop therapeutic strategies targeting toxic Aβ species. Its utility lies in modeling how residue-specific alterations contribute to amyloidosis, supporting insights into disease progression and the design of inhibitors for Alzheimer’s and related neurodegenerative disorders.

Chemical Formula: C203H311N55O60

Molecular Weight: 4482.07

Sequence: Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Val-Val-Gly-Gly-Val-Val-Ile-Ala

Purity: From crude to 98%

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