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α-Endorphin is a 16-residue endogenous POMC-derived peptide corresponding to β-Endorphin (1-16). Its sequence begins with the Met-enkephalin motif and extends through Thr16, providing a naturally defined intermediate between the five-residue enkephalin sequence and full-length 31-residue β-Endorphin.
Product Information
| Property | Specification |
|---|---|
| Product Name | α-Endorphin |
| Catalog No. | AS2587 |
| Synonym | β-Endorphin (1-16) |
| CAS No. | 61512-76-3 |
| Sequence | Tyr-Gly-Gly-Phe-Met-Thr-Ser-Glu-Lys-Ser-Gln-Thr-Pro-Leu-Val-Thr |
| One-Letter Sequence | YGGFMTSEKSQTPLVT |
| Peptide Length | 16 residues |
| Molecular Formula | C77H120N18O26S |
| Molecular Weight | Approximately 1745.9 Da |
| C-Terminus | Thr-OH |
A Defined β-Endorphin Processing Product
α-Endorphin is not a separate full-length POMC domain. It corresponds to the first 16 residues of β-Endorphin and is therefore particularly useful for studying how C-terminal truncation changes endorphin pharmacology.
From Met-Enkephalin to β-Endorphin
The sequence contains Met-enkephalin at residues 1-5 but lacks the extended C-terminal half of β-Endorphin. This creates a useful intermediate-length ligand for mapping how sequence extension beyond the core opioid motif changes receptor recognition and peptide degradation.
Analytical Considerations
Met5 is susceptible to oxidation. The peptide also contains no cysteine residues or disulfide bonds, so oxidative folding is not part of its intended molecular identity.
For defined fragment studies, our Peptide Quality Control capabilities support HPLC and MS characterization.
Frequently Asked Questions
Is α-Endorphin the same as β-Endorphin?
No. α-Endorphin corresponds to residues 1-16 of β-Endorphin, whereas intact β-Endorphin contains 31 residues.
Is α-Endorphin amidated?
No. It ends in Thr with a free carboxyl terminus.