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[Tyr8,Nle11] Substance P is a full-length Substance P analog containing two targeted substitutions: Phe8 is replaced by Tyr and the C-terminal Met11 is replaced by norleucine.
The analog preserves the 11-residue Substance P framework while introducing an aromatic phenolic residue at position 8 and removing the oxidation-sensitive sulfur atom from the C-terminal side chain.
Product Information
| Product Name | [Tyr8,Nle11] Substance P |
| Catalog No. | AS2577 |
| CAS No. | 71890-48-7 |
| Sequence | Arg-Pro-Lys-Pro-Gln-Gln-Phe-Tyr-Gly-Leu-Nle-NH2 |
| Short Sequence | RPKPQQFYGL-Nle-NH2 |
| Peptide Length | 11 residues |
| Molecular Formula | C64H100N18O14 |
| Molecular Weight | Approximately 1345.6 Da |
| Key Modifications | Phe8 → Tyr; Met11 → Nle |
| C-Terminus | Amidated |
| Research Use | Substance P / NK1 ligand analog |
| Purity Options | Crude to 98% |
Tyr8 Adds a Phenolic Aromatic Side Chain
Substance P normally contains Phe at both positions 7 and 8. Substitution of Phe8 with Tyr preserves the aromatic ring while introducing a para-hydroxyl group.
This provides a chemically distinct aromatic position that can be useful in ligand labeling and structure–activity experiments while leaving most of the Substance P pharmacophore unchanged.
Nle11 Removes the Methionine Oxidation Site
Met11 is replaced by norleucine, a hydrophobic non-sulfur amino acid. The substitution preserves a similar aliphatic side-chain geometry but eliminates formation of methionine sulfoxide or sulfone at the C-terminus.
We consider this particularly useful when the experiment depends on maintaining a chemically uniform C-terminal ligand population during storage or labeling workflows.
Research Applications
[Tyr8,Nle11] Substance P can support NK1 ligand studies, Substance P structure–activity research, receptor-binding experiments and development of labeled Substance P analogs.
The combination of Tyr8 and Nle11 makes this molecule chemically different from both [Tyr8]-Substance P and [Nle11]-Substance P, so these analogs should not be treated as interchangeable.
Frequently Asked Questions
Which residues are changed?
Phe8 is replaced by Tyr and Met11 is replaced by Nle.
Why is Nle11 useful?
Norleucine removes the sulfur atom present in methionine and therefore eliminates Met11 oxidation.
What does Tyr8 change?
Tyr retains an aromatic ring but adds a phenolic hydroxyl group relative to Phe8.
Is this full-length Substance P?
It is a full-length 11-residue Substance P analog with two substitutions.