Ac-Phe-Phe-OH; CAS 10030-31-6 is N-acetyl-L-phenylalanyl-L-phenylalanine, an N-capped aromatic dipeptide related to the widely studied diphenylalanine self-assembly motif.

N-acetylation changes terminal charge and intermolecular interaction patterns relative to free Phe-Phe, providing a defined derivative for aggregation, self-assembly and analytical comparison studies.

Product Information

Aromatic Self-Assembly and Stereochemical Context

Phenylalanine side chains support π-interactions and hydrophobic packing, which is why diphenylalanine is widely used in supramolecular peptide research. Configuration and terminal capping can change packing, morphology and solubility; comparisons should therefore use matched concentration, solvent history and purity.

What Changes with Configuration or Terminal Capping?

Self-assembly is sensitive to molecular geometry, solvent, concentration and sample history. A stereoisomer or N-capped derivative should therefore be treated as a distinct experimental system rather than as an interchangeable version of L-Phe-L-Phe.

Procurement and QC Considerations

For research use, match the requested purity and documentation to the experiment. Analytical or quantitative studies benefit from lot-specific HPLC and MS data, while metabolomics or sequence-isomer work may require additional identity controls.

For identity and purity documentation, review our peptide QC methods for HPLC and mass-spectrometric characterization principles.

For broader sequence or project work, see analytical peptide references.

Analytical Fit and Sample Preparation

For comparative or quantitative work, review the lot-specific purity method together with identity data. Chromatographic purity is method-dependent and should be interpreted separately from molecular-mass confirmation or gravimetric vial content.

Solvent and working concentration should be validated for the intended assay. Solution history can influence small peptide models through aggregation, oxidation or concentration-dependent behavior even when the dry material meets its release specification.

Product Documents

MSDS - Ac-Phe-Phe-OH (AS4040)

The Safety Data Sheet provides product identification, laboratory handling guidance, exposure controls, transport information and safety information for research use.

Certificates of Analysis (COAs) are batch-specific. Please contact us to request the COA for your product, and we will provide it by email.

Frequently Asked Questions

What is Ac-Phe-Phe-OH?

It is N-acetyl-L-phenylalanyl-L-phenylalanine, a defined research compound with sequence or structural identity Ac-Phe-Phe.

What is the main value of this product?

Its main value is as a chemically defined reference for aromatic dipeptide aggregation/self-assembly model.

What should be checked before quantitative use?

Confirm lot-specific identity, purity basis and analytical documentation appropriate to the method.

Research Use Only.