Angiotensin III, human is a heptapeptide (7 amino acids) derived from angiotensin II via enzymatic cleavage by aminopeptidase A in the renin-angiotensin system (RAS). While less potent than angiotensin II as a vasoconstrictor, it potently stimulates aldosterone secretion from the adrenal cortex, regulating sodium reabsorption, potassium excretion, and fluid balance—critical for blood pressure homeostasis. Acting through angiotensin type 1 (AT1) and type 2 (AT2) receptors, Angiotensin III also influences sympathetic nervous system activity and modulates cellular growth processes. In pharmacological research, human Angiotensin III serves as a tool to investigate RAS signaling specificity, aldosterone regulation, and the differential roles of angiotensin peptides in cardiovascular and renal physiology. Its role in electrolyte balance and blood pressure control highlights its importance in disorders like hypertension, hypovolemia, and adrenal dysfunction, while its synthesis and receptor interactions provide insights into therapeutic targeting of the RAS cascade.

Chemical Formula: C46H66N12O9

Molecular Weight: 931.10

Sequence: Arg-Val-Tyr-Ile-His-Pro-Phe

Purity: From crude to 98%

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