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Z-Tyr-OMe is N-Cbz-L-tyrosine methyl ester. The α-amino group is protected with Cbz (Z), the carboxyl group is capped as a methyl ester, and the tyrosine phenolic hydroxyl remains free.
With both backbone termini blocked, this compound is a useful protected intermediate for side-chain derivatization, solution-phase chemistry, or preparation of more specialized tyrosine building blocks. It is not directly configured for stepwise peptide-chain elongation until the appropriate terminus is deprotected.
Product Information
| Product Name | Z-Tyr-OMe |
| Chemical Name | N-Cbz-L-tyrosine methyl ester |
| Catalog No. | AS2012 |
| CAS No. | 13512-31-7 |
| Molecular Formula | C18H19NO5 |
| Molecular Weight | 329.35 g/mol |
| Compound Type | N-Cbz, C-terminal methyl-esterified L-tyrosine |
| Primary Research Use | Protected tyrosine intermediate for solution-phase synthesis and derivatization |
Protection Map and Side-Chain Access
Cbz protects the amino function and OMe protects the carboxyl group, leaving the phenolic OH as the main accessible tyrosine functionality. This can simplify O-functionalization or other aromatic/phenolic chemistry when backbone reactivity must be suppressed.
If the phenol also needs protection, a different tyrosine derivative should be selected rather than assuming the Cbz/OMe pattern covers the side chain.
Use in Solution-Phase Routes
The product can serve as a stable intermediate before selective deprotection, ester hydrolysis, or phenol derivatization. Cbz and methyl ester chemistry provides a route profile distinct from Fmoc/Tyr(tBu) reagents used in routine SPPS.
For chain-ready protected residues, review the specialty peptide building blocks category.
Identity and Procurement
CAS 13512-31-7 and the full “N-Cbz-L-tyrosine methyl ester” name help distinguish this material from Z-Tyr-OH, Tyr-OMe salts, and phenol-protected tyrosine derivatives.
Product Documents
The Safety Data Sheet provides product identification, hazard information, handling and storage guidance, exposure controls, transport information, and regulatory information for laboratory use.
Certificates of Analysis (COAs) are batch-specific. Please contact us to request the COA for your product, and we will provide it by email.
Frequently Asked Questions
What does OMe mean in Z-Tyr-OMe?
OMe indicates that the tyrosine carboxyl group is present as a methyl ester.
Is the tyrosine phenolic OH protected?
No. The phenolic hydroxyl remains free.
Can Z-Tyr-OMe be used directly for peptide-chain extension?
Not without deprotecting or transforming the relevant terminus; both the amino and carboxyl termini are blocked.