$123.00 - $1969.00
Z-Gln-Gly-OH, also written Cbz-Gln-Gly-OH, is an N-Cbz-protected Gln-Gly dipeptide with a free C-terminal glycine carboxyl group.
Its main value is sequence-specific fragment assembly: the Gln-Gly order is fixed before the fragment enters a larger target, reducing one downstream peptide-bond-forming step.
Product Information
| Product Name | Z-Gln-Gly-OH |
| Catalog No. | AS4185 |
| CAS No. | 6610-42-0 |
| Molecular Formula | C15H19N3O6 |
| Molecular Weight | 337.33 g/mol |
| Building Block Type | Cbz-protected Gln-Gly dipeptide fragment |
| Primary Applications | Protected fragment coupling; solution-phase peptide synthesis; Gln-Gly motif installation; peptide intermediate chemistry |
Sequence Order Is Fixed
Gln-Gly is not interchangeable with Gly-Gln. A preassembled fragment makes the residue order part of the reagent identity and can be useful when the same motif is repeated across several targets.
Cbz Protection Supports Reductive N-Deprotection
The N-terminal Gln amino group is Cbz-protected. Cbz is commonly removed reductively, so route compatibility should be checked when other reducible groups are present.
The Gln Side-Chain Amide Is Unprotected
The Gln side chain is present as its native amide rather than as a Trt-protected Asn/Gln derivative. Reaction conditions should therefore be selected with side-chain amide stability and potential dehydration chemistry in mind.
Procurement and QC
Confirm CAS 6610-42-0, C15H19N3O6, MW 337.33 g/mol, sequence Gln-Gly, N-terminal Cbz, and free C-terminal carboxyl.
Fragment use versus stepwise synthesis can be evaluated against the complete target in the SPPS practical guide.
Product Documents
A Safety Data Sheet (SDS / MSDS) is available for this product to support laboratory handling, storage and safety assessment.
Certificates of Analysis (COAs) are batch-specific. Please contact us to request the COA for your product, and we will provide it by email.
Frequently Asked Questions
What does Z mean?
Z is another name for the Cbz protecting group.
Which end is available for further coupling?
The C-terminal Gly carboxyl group is free.
Is Z-Gln-Gly-OH the same as Z-Gly-Gln-OH?
No. Sequence direction is part of the molecular identity.
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