$28.57 - $85.71
Z-Asn(Trt)-Gly-OH is a preassembled Asn-Gly dipeptide with N-terminal Cbz protection and trityl protection on the asparagine side-chain amide nitrogen. The C-terminal glycine carboxyl group remains available for further coupling, making the compound a protected short fragment rather than a fully blocked dipeptide.
The practical reason to purchase a fragment of this type is to move one peptide bond and part of the protecting-group control upstream. For routes that repeatedly require an Asn-Gly motif, a characterized dipeptide can reduce the number of downstream transformations and provide a separately controlled intermediate.
Product Information
| Product Name | Z-Asn(Trt)-Gly-OH |
| Catalog No. | AS4089 |
| CAS No. | 2414570-58-2 |
| Molecular Formula | C33H31N3O6 |
| Molecular Weight | 565.63 g/mol |
| Chemical Identity | Nα-Cbz-Nγ-Trt-L-Asn-Gly-OH |
| Building Block Type | Cbz/Trt-protected dipeptide fragment |
| Primary Applications | Protected-fragment synthesis, convergent peptide assembly and solution-phase coupling |
Why a Preformed Asn-Gly Bond Can Be Useful
Asn-containing sequences can show condition-dependent side chemistry during longer syntheses. Starting from a defined Asn-Gly fragment does not eliminate every downstream risk, but it allows the identity of this short motif to be established before the fragment is incorporated into a larger molecule. For laboratories deciding between stepwise and fragment approaches, our SPPS workflow guide provides the complementary stepwise synthesis framework.
Cbz and Trt Protect Different Functional Groups
The N-terminal Cbz group and side-chain Trt group are chemically distinct protections with different removal conditions. Cbz is commonly removed reductively, while Trt is acid-labile. We recommend planning these operations against every other sensitive group in the intermediate rather than treating “Z-Asn(Trt)” as a single deprotection event.
Analytical Control Is Especially Important for Sparse-Index Products
Public indexing for unusual protected dipeptides can be limited. For AS4089, the lot-specific COA and structure therefore carry more weight than generic database matching. LC-MS can confirm nominal mass, HPLC can support purity assessment, and NMR or other structure-level information may be useful when the route is sequence-critical. This procurement logic is consistent with our broader discussion of how deletion products and side chemistry complicate peptide identity.
Procurement and QC Considerations
Confirm CAS 2414570-58-2, C33H31N3O6, MW 565.63 g/mol, L-Asn stereochemistry, free C-terminal Gly carboxyl and the exact locations of Cbz and Trt protection. We consider the drawn structure and lot-specific chromatographic data essential for this SKU because closely related protected Asn fragments may not be distinguishable from abbreviated naming alone.
Product Documents
A Safety Data Sheet (SDS / MSDS) is available for this product to support laboratory handling, storage and safety assessment.
Certificates of Analysis (COAs) are batch-specific. Please contact us to request the COA for your product, and we will provide it by email.
Frequently Asked Questions
Is the Gly carboxyl group free?
Yes. The C-terminal glycine carboxyl group is the main handle for downstream activation and coupling.
Are Cbz and Trt removed under the same conditions?
No. Cbz is generally removed reductively, whereas Trt is acid-labile.
Why use the Asn-Gly dipeptide instead of two separate amino acids?
A preformed fragment removes one downstream peptide-bond-forming step and allows the Asn-Gly unit to be characterized before it enters a longer route.
Related Technical Resources
Explore other protected dipeptides and convergent peptide building blocks, or send a target sequence through our custom peptide synthesis service for route evaluation.