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Z(4-NO2)-OSu (CAS 75679-31-1) is the N-hydroxysuccinimide ester of 4-hydroxy-3-nitrophenylacetic acid, also described in immunochemical literature as an NP-OSu-type activated ester.
The NHS ester reacts with primary amines, making it useful for hapten installation and amine-directed conjugation rather than peptide-chain elongation as an amino-acid monomer.
Product Information
| Product Name | 4-hydroxy-3-nitrophenylacetyl-OSu |
| Catalog No. | AS3021 |
| CAS No. | 75679-31-1 |
| Molecular Formula | C12H10N2O7 |
| Molecular Weight | 294.22 g/mol |
| Material / Building Block Type | NHS ester of 4-hydroxy-3-nitrophenylacetic acid |
| Primary Applications | Amine labeling; nitrophenylacetyl hapten conjugation; immunochemistry reagent preparation; activated-ester bioconjugation |
Application Scope in Hapten and Amine Labeling
Activated nitrophenylacetyl NHS esters have been used to install NP-type haptens on proteins, peptides and other amino-containing molecules for immunochemistry and binding studies. Labeling stoichiometry depends on pH, reagent excess and amine accessibility.
NHS Ester Reactivity
The succinimidyl ester reacts with nucleophilic amines but also hydrolyzes in water. Dry handling, freshly prepared solutions and controlled reaction pH help preserve effective labeling capacity.
Identity and QC
Confirm CAS 75679-31-1, molecular formula C12H10N2O7, molecular weight 294.22 g/mol and the 4-hydroxy-3-nitrophenylacetyl-OSu structure. Because NHS esters can hydrolyze, select purity, handling and storage conditions appropriate to the intended labeling workflow.
Product Documents
A Safety Data Sheet (SDS / MSDS) is available for this product to support laboratory handling, storage and safety assessment.
4-hydroxy-3-nitrophenylacetyl-OSu MSDS
Certificates of Analysis (COAs) are batch-specific. Please contact us to request the COA for your product, and we will provide it by email.
Frequently Asked Questions
What does OSu mean?
An N-hydroxysuccinimide activated ester.
What is the primary application?
Amine-directed installation of a nitrophenylacetyl/NP-type hapten.
Why should aqueous exposure be minimized?
Water hydrolyzes the activated NHS ester.
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