$28.57 - $85.71
Ac-OSu, also known as N-succinimidyl acetate or succinimidyl acetate, is an activated N-hydroxysuccinimide ester of acetic acid. It transfers an acetyl group to suitable nucleophilic amines and provides a convenient research reagent for controlled acetylation chemistry.
In peptide and bioconjugation workflows, Ac-OSu is relevant when the objective is to generate N-acetylated peptide termini, amino-acid derivatives or other amine-containing molecules. Its role is chemical acetylation; it should not be confused with NHS itself, which is an additive/active-ester precursor rather than an activated acetate donor.
Product Information
| Product Name | Ac-OSu |
| Catalog No. | AS3006 |
| CAS No. | 14464-29-0 |
| Molecular Formula | C6H7NO4 |
| Molecular Weight | 157.12 g/mol |
| Building Block Type | N-hydroxysuccinimide active ester |
| Chemical Identity | N-Succinimidyl acetate; acetic acid N-hydroxysuccinimide ester |
| Primary Applications | Acetylation of amines, peptide/protein modification and preparation of N-acetylated intermediates |
How Ac-OSu Works
The succinimidyl ester is an activated carboxylic-acid derivative. A suitable amine attacks the acetyl carbonyl, forming an amide while N-hydroxysuccinimide acts as the leaving group. Reaction rate and selectivity depend on amine nucleophilicity, solvent, pH/base, water content and competing nucleophiles.
Applications in Peptide and Protein Modification
Ac-OSu can be used to prepare N-acetylated peptides, amino-acid derivatives and model amides, and it is also useful in research workflows involving protein or peptide acetylation. In biological studies, the purified acetylated product - not Ac-OSu itself - may be used to investigate how acetylation changes recognition, charge, conformation or analytical behavior.
Ac-OSu vs NHS
NHS (N-hydroxysuccinimide) does not itself carry an acetyl group. Ac-OSu is the pre-formed NHS ester of acetic acid and is therefore an acetyl-transfer reagent. This distinction matters when searching for an acetylation reagent versus a coupling additive used to make other NHS esters.
Hydrolysis and Handling
Like other activated NHS esters, Ac-OSu can be consumed by hydrolysis in the presence of water. Dry handling and appropriately controlled reaction conditions can therefore improve reagent efficiency. Product quality should be assessed together with storage and moisture exposure rather than by nominal assay alone.
Safety and Procurement Considerations
Current supplier safety information commonly classifies N-succinimidyl acetate as harmful if swallowed and as a skin, eye and respiratory irritant. Review the product-specific MSDS before weighing or handling the solid, and confirm CAS 14464-29-0 and lot-specific analytical identity on the COA.
Product Documents
A Material Safety Data Sheet (MSDS) is available for this product to support laboratory handling, storage and safety assessment.
Certificates of Analysis (COAs) are batch-specific. Please contact us to request the COA for your product, and we will provide it by email.
Frequently Asked Questions
What is Ac-OSu?
Ac-OSu is N-succinimidyl acetate, an activated acetate ester used to acetylate suitable amines.
Is Ac-OSu the same as NHS?
No. NHS is N-hydroxysuccinimide; Ac-OSu is the NHS ester of acetic acid and functions as an acetyl donor.
Can Ac-OSu be used to prepare N-acetylated peptides?
Yes, when the relevant peptide amine is accessible and the reaction conditions are compatible with the target molecule.
Related Technical Resources
Browse additional Specialty Peptide Building Blocks for protected fragments, non-natural residues and peptide-synthesis intermediates.
For projects using this chemistry in a complete research workflow, explore Alan Scientific's peptide synthesis and modification projects.