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[Met5,Lys6,Arg7]-α-Neo-Endorphin (1-7) is a seven-residue synthetic sequence also known as Met-Enkephalin-Lys-Arg. Its sequence, Tyr-Gly-Gly-Phe-Met-Lys-Arg, combines the Met-enkephalin pentapeptide with a Lys-Arg C-terminal extension.
This molecular identity makes the peptide particularly useful for comparing Met-enkephalin-derived and α-Neoendorphin-derived sequence motifs.
Product Information
| Property | Specification |
|---|---|
| Product Name | [Met5,Lys6,Arg7]-α-Neo-Endorphin (1-7) |
| Catalog No. | AS2559 |
| Synonym | Met-Enkephalin-Lys-Arg |
| CAS No. | 83404-42-6 |
| Sequence | Tyr-Gly-Gly-Phe-Met-Lys-Arg |
| One-Letter Sequence | YGGFMKR |
| Peptide Length | 7 residues |
| Molecular Formula | C39H59N11O9S |
| Molecular Weight | Approximately 858.0 Da |
| C-Terminus | Arg-OH |
Three Substitutions Relative to α-Neoendorphin (1-7)
Native α-Neoendorphin (1-7) is YGGFLRK. This analog replaces Leu5 with Met, Arg6 with Lys and Lys7 with Arg.
These coordinated substitutions switch the core from a Leu-enkephalin-type sequence to a Met-enkephalin sequence while preserving a strongly basic two-residue extension.
Useful for Enkephalin Extension Studies
The Lys-Arg tail provides a defined way to investigate how basic residues positioned immediately after Met-enkephalin alter peptide charge, receptor interaction and protease recognition.
It can be compared directly with Met-enkephalin, Met-Enkephalin-Lys-Lys and α-Neoendorphin (1-7).
Analytical Considerations
Met5 introduces a sulfur-containing residue that can undergo oxidation. LC-MS is useful for distinguishing the intended peptide from oxidized Met-containing species.
Frequently Asked Questions
Is this sequence also called Met-Enkephalin-Lys-Arg?
Yes. YGGFMKR is commonly cataloged under that name.
Is the C-terminus amidated?
No. The listed peptide terminates in Arg-OH.