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[Tyr0]-Neurokinin B is an 11-residue analog containing an additional N-terminal tyrosine before the complete Neurokinin B sequence. The resulting sequence is Tyr-Asp-Met-His-Asp-Phe-Phe-Val-Gly-Leu-Met-NH₂.
The Tyr0 extension provides a defined aromatic phenolic residue without replacing any residue of the native NKB backbone, making the analog useful for ligand-probe development and comparative NK3 receptor studies.
Product Information
| Property | Specification |
|---|---|
| Product Name | [Tyr0]-Neurokinin B |
| Catalog No. | AS2573 |
| CAS No. | 131019-53-9 |
| Sequence | Tyr-Asp-Met-His-Asp-Phe-Phe-Val-Gly-Leu-Met-NH₂ |
| One-Letter Sequence | YDMHDFFVGLM-NH₂ |
| Peptide Length | 11 residues |
| Molecular Formula | C64H88N14O16S2 |
| Molecular Weight | Approximately 1373.6 Da |
| Modification | Added N-terminal Tyr0 |
| Reference Receptor | NK3R |
A Tyr Residue Added without Removing Native NKB Sequence
The complete ten-residue NKB sequence remains intact at positions 1-10 of the original ligand. Tyr0 is introduced as an extra residue before Asp1.
This is distinct from a point-mutated NKB analog because no native residue is replaced.
A Defined Phenolic Handle for Probe Chemistry
Native NKB contains no tyrosine. Addition of Tyr0 introduces a phenolic side chain that can provide a useful chemical handle in labeling and ligand-detection workflows.
Any derivatization or radiolabeling strategy should still be validated for receptor affinity because modification of the N-terminal extension can influence ligand behavior.
Comparison with Native NKB
For quantitative NK3R studies, native Neurokinin B should be included as a reference. The Tyr0 analog has a different mass, charge distribution and N-terminal chemistry even though the endogenous sequence remains present.
Frequently Asked Questions
Is Tyr0 part of native Neurokinin B?
No. It is an additional residue placed before native Asp1.
Does this analog still contain the full NKB sequence?
Yes. All ten native NKB residues remain present.