[Tyr0]-Neurokinin A is an 11-residue analog of full-length Neurokinin A with an additional tyrosine attached before native His1. Its sequence is Tyr-His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met-NH₂.

The modification preserves the complete ten-residue NKA backbone while introducing a defined N-terminal aromatic residue for probe-oriented and comparative receptor studies.

Product Information

Full-Length NKA Backbone Retained

Unlike NKA (4-10), which removes the first three endogenous residues, [Tyr0]-NKA preserves His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met-NH₂ in full and adds Tyr before His1.

This allows studies to retain the native NKA sequence while introducing an additional chemically accessible N-terminal side chain.

Useful for NKA Probe Development

Native Neurokinin A contains no tyrosine. The Tyr0 extension introduces a phenolic group that can be exploited in peptide-labeling strategies while leaving the endogenous ten-residue sequence unchanged.

Because the molecule is no longer chemically identical to NKA, receptor binding and signaling should be validated experimentally rather than assumed from the parent ligand.

Comparison with NKA (4-10)

[Tyr0]-NKA and NKA (4-10) serve different experimental roles. The former retains the complete endogenous backbone and adds one residue; the latter removes the native N-terminal three residues to isolate the C-terminal pharmacophore.

Custom labeled tachykinin probes can be evaluated through Chemical Peptide Synthesis.

Frequently Asked Questions

Does [Tyr0]-Neurokinin A contain all ten native NKA residues?

Yes. Tyr is added before His1 rather than replacing a native residue.

Is Tyr0 part of endogenous Neurokinin A?

No. It is a synthetic N-terminal extension.

Research Use Only.