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Neurokinin Receptor (393-407), rat is a 15-residue peptide corresponding to the intracellular C-terminal region of the rat neurokinin-1 receptor (NK1R). Its sequence is Lys-Thr-Met-Thr-Glu-Ser-Ser-Ser-Phe-Tyr-Ser-Asn-Met-Leu-Ala.
This peptide is a receptor-derived epitope fragment rather than a tachykinin ligand. It is particularly relevant to antibody development, receptor localization and studies of NK1R trafficking.
Product Information
| Property | Specification |
|---|---|
| Product Name | Neurokinin Receptor (393-407), Rat |
| Catalog No. | AS2712 |
| Synonym | Rat NK1R (393-407); SPR393-407 |
| CAS No. | 153607-26-2 |
| Sequence | Lys-Thr-Met-Thr-Glu-Ser-Ser-Ser-Phe-Tyr-Ser-Asn-Met-Leu-Ala |
| One-Letter Sequence | KTMTESSSFYSNMLA |
| Peptide Length | 15 residues |
| Molecular Formula | C72H113N17O26S2 |
| Molecular Weight | Approximately 1696.9 Da |
| Protein Context | Rat NK1 receptor intracellular C-terminal tail |
An NK1 Receptor Epitope, Not a Tachykinin Agonist
The peptide derives from residues 393-407 of the receptor protein itself. It should therefore be distinguished from Substance P, Neurokinin A and Neurokinin B, which are extracellular tachykinin ligands.
The receptor fragment does not reproduce the seven-transmembrane GPCR architecture and should not be described as a functional NK1 receptor or as an NK1 agonist.
Antibody Generation and Receptor Localization
The NK1R C-terminal peptide was used in classical studies to generate receptor-specific antisera. These antibodies enabled visualization of receptor distribution and trafficking in tissues and transfected cells.
This makes the peptide useful as an immunogen-related antigen, antibody-blocking control or defined epitope in receptor-localization workflows.
Receptor Trafficking Context
After Substance P activates intact NK1R, the receptor can undergo endocytosis and later recycle toward the plasma membrane. The C-terminal receptor region participates in intracellular regulatory processes, but these trafficking events occur in the intact receptor, not in the isolated 15-residue peptide itself.
Analytical Considerations
The sequence contains two methionine residues, so oxidation should be monitored when the peptide is used as a precise antibody-recognition standard.
Frequently Asked Questions
Is this peptide an NK1 receptor agonist?
No. It is a peptide fragment derived from the intracellular C-terminal tail of rat NK1R.
How many residues are present?
The correct sequence KTMTESSSFYSNMLA contains 15 residues.