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Fmoc-O-methyl-L-serine (CAS 159610-93-2) is a Protected amino-acid / peptidomimetic building block used in peptide, peptidomimetic and medicinal-chemistry synthesis. Its main synthetic value is a noncanonical or specially protected residue used to expand peptide and small-molecule chemical space.
Use when the target structure specifically requires this residue or protection pattern; confirm stereochemistry and deprotection compatibility before substituting it into an established route. Procurement should match the exact CAS, protection state and lot-specific analytical specification to the intended route.
Product Information
| Product Name | Fmoc-O-methyl-L-serine |
| Catalog No. | AS4226 |
| CAS No. | 159610-93-2 |
| Molecular Formula | C19H19NO5 |
| Molecular Weight | 341.36 g/mol |
| Compound Type | Protected amino-acid / peptidomimetic building block |
| Primary Research Use | Peptide, peptidomimetic and medicinal-chemistry synthesis |
Residue Design and Application
Fmoc-O-methyl-L-serine is relevant when the target structure requires a noncanonical or specially protected residue used to expand peptide and small-molecule chemical space. Its value comes from the residue identity itself, not simply from carrying a standard Fmoc or Boc group.
Protection Strategy
The protecting group controls which functionality remains available during coupling and which cleavage chemistry is required later. Check the complete protection scheme before substituting this material for a related amino acid.
Sequence-Level Decision
Use this derivative when its side chain, backbone spacing or stereochemistry is part of the design hypothesis. For routine sequences, the corresponding standard residue is usually the simpler choice.
Related options are grouped under unusual amino acid range. For broader route support, see advanced peptide building blocks.
Product Documents
MSDS - Fmoc-O-methyl-L-serine (AS4226)
The Safety Data Sheet provides product identification, hazard information, handling and storage guidance, exposure controls, transport information, and regulatory information for laboratory use.
Certificates of Analysis (COAs) are batch-specific. Please contact us to request the COA for your product, and we will provide it by email.
Frequently Asked Questions
What is Fmoc-O-methyl-L-serine mainly used for?
Peptide, peptidomimetic and medicinal-chemistry synthesis.
What is the critical identity check?
Confirm CAS 159610-93-2, stereochemistry or positional isomer where applicable, and the complete protection state.
What documentation should be matched to the lot?
Use the COA to confirm assay and analytical identity; the nominal formula is C19H19NO5 with molecular weight 341.36 g/mol.