$310.00 - $2796.00
Fmoc-D-Lys(Me,Boc)-OH is N2-Fmoc-N6-Boc-N6-methyl-D-lysine. The side-chain ε-nitrogen carries a methyl group that remains in the final residue and a Boc group that protects it during synthesis.
The building block combines D stereochemistry with monomethylated lysine side-chain chemistry, allowing both backbone configuration and lysine N-methylation to be explored in peptide SAR.
Product Information
| Product Name | Fmoc-D-Lys(Me,Boc)-OH |
| Catalog No. | AS2152 |
| CAS No. | 2044709-77-3 |
| Molecular Formula | C27H34N2O6 |
| Molecular Weight | 482.57 g/mol |
| Material / Building Block Type | Fmoc-protected N6-methyl/N6-Boc D-lysine |
| Primary Applications | D-lysine peptide SAR; side-chain monomethyl-lysine analogs; protease-stability studies; modified-lysine peptide synthesis |
Application Scope in Modified Lysine SAR
The reagent is useful for D-lysine analogs where ε-N-methylation is part of the final design. It can support studies of side-chain basicity, steric recognition, protease resistance and modified-lysine binding motifs.
Protection Map and Deprotection
Fmoc protects the α-amino group; Boc protects the already methylated ε-nitrogen. After final deprotection, the N6-methyl substituent remains while Boc is removed.
Procurement and QC
PubChem confirms CAS 2044709-77-3, C27H34N2O6, MW 482.6 g/mol and the N6-Boc-N6-methyl-D-lysine topology. D stereochemistry cannot be established by mass alone.
For D-lysine and side-chain-methylated peptide analogs, Alan Scientific can support custom modified peptide synthesis.
Product Documents
A Safety Data Sheet (SDS / MSDS) is available for this product to support laboratory handling, storage and safety assessment.
Certificates of Analysis (COAs) are batch-specific. Please contact us to request the COA for your product, and we will provide it by email.
Frequently Asked Questions
Where is the methyl group?
On the lysine side-chain N6/ε-nitrogen.
Does the methyl remain after deprotection?
Yes.
Is this the L-lysine analog?
No. It is D-lysine.