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[Pyr5]-Substance P (5-11) is a seven-residue C-terminal Substance P analog with the sequence Pyr-Gln-Phe-Phe-Gly-Leu-Met-NH2. It contains an N-terminal pyroglutamate at the position corresponding to residue 5 of the native peptide.
The peptide provides a compact model for studying the C-terminal region of Substance P while removing the basic N-terminal Arg-Pro-Lys-Pro sequence of the full-length neuropeptide.
Product Information
| Product Name | [Pyr5]-Substance P (5-11) |
| Catalog No. | AS2565 |
| CAS No. | 56104-22-4 |
| Sequence | Pyr-Gln-Phe-Phe-Gly-Leu-Met-NH2 |
| Peptide Length | 7 residues |
| Molecular Formula | C41H57N9O9S |
| Molecular Weight | Approximately 852.0 Da |
| N-Terminus | Pyroglutamate |
| C-Terminus | Amidated |
A Seven-Residue C-Terminal Substance P Scaffold
The peptide contains one additional residue compared with [Pyr6]-Substance P (6-11). This changes the N-terminal boundary of the fragment while leaving the Phe-Phe-Gly-Leu-Met-NH2 C-terminal region intact.
C-terminal Substance P fragments have been used to examine how different portions of the neuropeptide contribute to receptor activation, neuronal signaling and peptide processing.
We recommend treating [Pyr5]-SP(5-11) as a distinct chemical analog rather than assuming that results obtained with the native SP(5-11) fragment apply directly. Cyclization to pyroglutamate removes the free N-terminal amine and changes the charge and hydrogen-bonding properties of the molecule.
Research Applications
[Pyr5]-Substance P (5-11) can support Substance P fragment studies, peptide processing research, tachykinin structure–activity experiments and comparisons of different C-terminal peptide boundaries.
The peptide retains Met11. Methionine oxidation should therefore be considered when interpreting aged samples or experiments sensitive to chemical homogeneity.
Frequently Asked Questions
What is the sequence of [Pyr5]-Substance P (5-11)?
The sequence is Pyr-Gln-Phe-Phe-Gly-Leu-Met-NH2.
What is the difference between Pyr and Gln?
Pyroglutamate is a cyclic residue. Conversion of an N-terminal Gln to pyroglutamate removes the free α-amino group and changes the chemical properties of the peptide terminus.
Is this the same as Substance P (5-11)?
No. The Pyr5 modification makes it chemically distinct from a fragment retaining an uncyclized N-terminal Gln.
Does the peptide contain methionine?
Yes. Met11 is retained at the amidated C-terminus.