[Pyr5]-Substance P (5-11) is a modified analog of the heptapeptide Substance P (5-11), featuring a pyroglutamic acid (Pyr) residue at position 5. This modification enhances stability and resistance to enzymatic degradation while preserving bioactivity through interactions with neurokinin-1 (NK-1) receptors. It plays a role in modulating pain signaling, inflammatory responses, and immune functions. Employed in pharmacological research, this analog aids in investigating receptor activation mechanisms and exploring therapeutic potential for pain management and inflammatory disorders.

Chemical Formula: C41H57N9O9S

Molecular Weight: 852.05

Sequence: Pyr-Gln-Phe-Phe-Gly-Leu-Met-NH2

Purity: From crude to 98%

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Research Use Only