[D-Pro2,D-Trp6,8,Nle10]-Neurokinin B is a synthetic analog of Neurokinin B with D-isomer substitutions at positions 2, 6, and 8 (D-proline, D-tryptophan) and norleucine (Nle) at position 10. These modifications enhance stability, resistance to enzymatic degradation, and binding specificity for neurokinin-3 (NK-3) receptors. This analog retains bioactivity in modulating pain signaling, inflammatory responses, and cardiovascular regulation. Utilized in pharmacological research, it serves as a tool to investigate structure-activity relationships, receptor activation mechanisms, and explore therapeutic potential for pain management, inflammatory disorders, and cardiovascular conditions.

Chemical Formula: C67H87N15O14

Molecular Weight: 1326.53

Sequence: Asp-D-Pro-His-Asp-Phe-D-Trp-Val-D-Trp-Leu-Nle-NH2

Purity: From crude to 98%

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Research Use Only