[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P is a highly modified analog of Substance P, incorporating D-arginine at position 1, D-phenylalanine at position 5, D-tryptophan at positions 7 and 9, and leucine at position 11. These substitutions enhance its stability, receptor-binding affinity for neurokinin-1 (NK-1) receptors, and selectivity in modulating pain signaling, inflammation, and immune responses. Widely used in pharmacological research, this analog serves as a tool to investigate structure-activity relationships and explore therapeutic potential in analgesic and anti-inflammatory drug development.

Chemical Formula: C79H109N19O12

Molecular Weight: 1516.87

Sequence: D-Arg-Pro-Lys-Pro-D-Phe-Gln-D-Trp-Phe-D-Trp-Leu-Leu-NH2

Purity: From crude to 98%

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Research Use Only