[Nle11] Substance P is a modified analog of Substance P with norleucine (Nle) substituted at position 11, replacing the native methionine (Met). This modification enhances stability, resistance to enzymatic degradation, and receptor-binding affinity for neurokinin-1 (NK-1) receptors while preserving bioactivity in modulating pain signaling, inflammatory responses, and immune functions. Utilized in pharmacological research, it serves as a tool to investigate structure-activity relationships and explore therapeutic potential for analgesic and anti-inflammatory drug development.

Chemical Formula: C64H100N18O13

Molecular Weight: 1329.62

Sequence: Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Nle-NH2

Purity: From crude to 98%

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Research Use Only