α-Neoendorphin (1-8) is a truncated opioid neuropeptide derived from α-Neoendorphin, spanning residues 1–8. This bioactive fragment retains the ability to interact with μ, δ, and κ opioid receptors, mediating analgesic effects, mood regulation, and immune modulation. Its truncated form enhances stability and resistance to enzymatic degradation while preserving receptor-binding specificity. In pharmacological research, α-Neoendorphin (1-8) serves as a tool to investigate opioid receptor activation mechanisms, structure-activity relationships, and the functional contributions of N-terminal residues in peptide signaling. It holds potential for exploring therapeutic applications in pain management, addiction therapies, and psychiatric disorders, leveraging its truncated design to focus on receptor specificity and bioactivity optimization.

Chemical Formula: C49H70N12O11

Molecular Weight: 1003.17

Sequence: Tyr-Gly-Gly-Phe-Leu-Arg-Lys-Tyr

Purity: From crude to 98%

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