[Tyr6,D-Phe7,D-His9]-Substance P (6-11) is a modified analog of the hexapeptide Substance P (6-11), incorporating tyrosine (Tyr) at position 6, D-phenylalanine (D-Phe) at position 7, and D-histidine (D-His) at position 9. These substitutions enhance its stability, resistance to enzymatic degradation, and binding specificity for neurokinin-1 (NK-1) receptors. This analog retains bioactivity in modulating pain signaling, inflammatory responses, and immune functions. Utilized in pharmacological research, it serves as a tool to investigate structure-activity relationships, receptor activation mechanisms, and explore therapeutic potential for analgesic and anti-inflammatory drug development.

Chemical Formula: C44H57N9O7S

Molecular Weight: 856.07

Sequence: Tyr-D-Phe-Phe-D-His-Leu-Met-NH2

Purity: From crude to 98%

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Research Use Only