MART-1 (27-35) (human) is a 9-amino acid peptide derived from the Melan-A/MART-1 protein, a melanoma-associated antigen expressed in melanocytes and melanoma cells. This peptide constitutes a critical antigenic epitope that binds to major histocompatibility complex (MHC) class I molecules, such as HLA-A*02:01, for presentation to cytotoxic T lymphocytes (CTLs). Recognized as a tumor-specific antigen, MART-1 (27-35) plays a key role in immunotherapeutic approaches targeting melanoma, including peptide-based vaccines and adoptive T-cell therapies, by stimulating CTL-mediated destruction of cancer cells. In research, it is used to investigate T-cell receptor specificity, optimize antigen presentation pathways, and enhance anti-tumor immune responses. Its significance lies in its ability to serve as a target for harnessing the immune system against melanoma, with ongoing efforts to improve its immunogenicity and therapeutic efficacy in clinical applications.

Chemical Formula: C37H67N9O11

Molecular Weight: 814.00

Sequence: Ala-Ala-Gly-Ile-Gly-Ile-Leu-Thr-Val

Purity: From crude to 98%

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Research Use Only